The Shangguo Hou Lab 



  1. Shangguo Hou, Jack Exell, Kevin Welsher. Real-time 3D Single Molecule Tracking. Nature Communications, 2020, 11, 3607 (Reported by Duke Research) (PDF)

  2. Shangguo Hou, Kevin Welsher. An Adaptive Real-Time 3D Single Particle Tracking Method for Monitoring Viral First Contacts. Small, 2019, 15, 1903039

  3. Shangguo Hou, Courtney Johnson, Kevin Welsher. Real-Time 3D Single Particle Tracking: Towards Active Feedback Single Molecule Spectroscopy in Live Cells. Molecules, 2019, 24, 2826

  4. Shangguo Hou, Kevin Welsher. A Protocol for Real-time 3D Single Particle Tracking. J. Vis. Exp., 2018, 131, e56711

  5. Shangguo Hou, Xiaoqi Lang, Kevin Welsher. Robust real-time 3D single-particle tracking using a dynamically moving laser spot. Optics Letters, 2017, 42, 2390-2393. (Reported by Duke Research, et. al.)

  6. Siddharth Patel, N Ashwanikumar, Ema Robinson, Yan Xia, Cosmin Mihai, Joseph Griffith III, Shangguo Hou, Adam Esposito, Tatiana Ketova, Kevin Welsher, John Joyal, Orn Almarsson, Gaurav Sahay. Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. Nature Communications, 2020, 11, 983

  7. Shangguo Hou, Jianfang Chen, Suhui Deng, Fei Wang, Qing Huang, Ya Cheng, Chunhai Fan. Improved resolution in fluorescence microscopy with the FRET pairs by time gating. Optics Express, 2015, 23, 13121-13129

  8. Shangguo Hou, Le Liang, Suhui Deng, Jianfang Chen, Qing Huang, Ya Cheng, Chunhai Fan. Nanoprobes for super-resolution fluorescence imaging at the nanoscale. SCIENCE CHINA Chemistry, 2014, 57, 100-106.

  9. Jiancong Du, Suhui Deng, Shangguo Hou, Lingling Qiao, Jianfang Chen, Qing Huang, Chunhai Fan, Ya Cheng, Yun Zhao. Superresolution imaging of DNA tetrahedral nanostructures in cells by STED method with continuous wave lasers. Chinese Optics Letters, 2014, 12, 041101

  10. Shangguo Hou, Kun Wang, Lihua Wang, Qing Huang, Suhui Deng. The principle and the application of time gating in nanoscopy. SCIENTIA SINICA Chimica, 2015, 45, 1206-1213

  11. Shaopeng Wang, Suhui Deng, Xiaoqing Cai, Shangguo Hou, Jiajun Li, Zhaoshuai Gao, Jiang Li, Lihua Wang, Chunhai Fan. Superresolution imaging of telomeres with continuous wave stimulated emission depletion (STED) microscope. SCIENCE CHINA Chemistry, 2016, 59, 151991524

  12. Sisi Jia, Le Liang, Shangguo Hou, Suhui Deng, Huajie Liu, Qing Huang, Chumhai Fan. Study on the imaging of subcellular organelles with superresolution microscopy. Journal of Radiation Research and Radiation Processing, 2014, 32, 40101-040101


  1. Shangguo Hou, Suhui Deng, Ya Cheng, Qing Huang and Chunhai Fan. Saturated resonance energy transfer super-resolution probe and preparation method and application thereof. CN 106290988 A


  1. FIP Special Postdoc Seminar, May 2020 (Seminar oral Presentation)
    Title: “Real-time 3D single-particle and single-molecule tracking”

  1. The Fitzpatrick Institute for Photonics Annual Symposium, March 2020 (poster)
    Title: “Real-time 3D Single Molecule Tracking Microscopy”, won Honorable Mention prize in poster competition

  2. 64th Annual Meeting of the Biophysical Society, February 2020 (Platform oral presentation)
    Title: ‘‘Active feedback 3D single-molecule tracking’’

  3. The Fitzpatrick Institute for Photonics Annual Symposium, March 2019 (poster)
    Title: “Observing single DNA transcription events in solution with real-time 3D single molecule tracking microscopy”

  4. 62th Annual Meeting of the Biophysical Society, February 2018 (Poster)
    Title: ‘‘Adaptive precision real-Time 3D single particle tracking microscopy’’

  5. The Fitzpatrick Institute for Photonics Annual Symposium, March 2018 (poster)
    Title: “Observing virus landing on cell membrane with adaptive precision real-time 3D single particle tracking microscopy”, won 3rd prize in poster competition